intervertebraldiscdegeneration相关论文
目的:探讨显微镜辅助微创前路腰椎间盘切除减压零切迹融合术（anterior lumbar discectomy and fusion，ALDF）治疗腰椎退变性疾病的疗效......
目的:探讨退行性腰椎侧凸患者椎旁肌的变化，以及其与腰椎后凸的相关性。方法:回顾性分析67例退行性腰椎侧凸（degenerative lumbar sc......
The Involvement of Protease Nexin-1 (PN-1) in the Pathogenesis of Intervertebral Disc (IVD) Degenera
Objective Protease Nexin-1(PN-1)has been found to interact with both extracellular matrix(ECM)and intracellular cartilag......
Factor-Inhibiting Hypoxia-Inducible Factor-1modulates Catabolic Effects of Tumor Necrosis Factor-alp
Bcakground: In degenerative intervertebral disc,the hypoxia inducible factors(HIFs)are the important factors involved in......
Bcakground: Both hypoxia and the marked increase of inflammatory cytokines are the common hallmarks of intervertebral di......
Purpose:Low back pain is a common intervertebral disc degenerative disease.Apoptosis of nucleus pulposus cells plays an ......
Background:Histone deacetylase inhibitors (HDACi), a new class of anti-cancer agents, have recently been reported to exh......
Background Intervertebral disc degeneration(IDD)is a common cause of low back pain.Patients who fail expectant treatment......
Object:This study aimed to reveal the possible genes associated with the pathogenesis of intervertebral disc degeneratio......
Objective: The intervertebral disc(IVD)is vascularized by blood vessels.This study aimed to identify angiogenic factors ......
Objective To compare post-operative clinical outcomes between bone cement augmented pedicle screw and traditional pedicl......
Hypoxia differentially regulates the metabolism of human nucleus pulposus cells under basal and IL-1
Objective: HIF-2α has been shown to exhibit robust expression in human nucleus pulposus (NP) tissue, regulating the met......
Middle term follow-up results analysis after selective posterior decompression and fusion in the tre
Objective To investigate middle term follow-up clinical results of selective posterior decompression,pedicle screw fixat......
Mesenchymal stem cells regulate mechanical properties of human degenerated nucleus pulposus cells th
Transplantation of mesenchymal stem cells(MSCs)into the degenerated intervertebral disc(IVD)has shown promise for decele......
Noncoding RNA AS-ADAMTS5 cooperates with RREB1to promote intervertebral disc degeneration through fa
Objective: Previous studies have indicated the important roles of ADAMTS5 in intervertebral disc degeneration (IDD) and ......
Blocking the Function of Inflammatory Cytokines and Mediators by Using IL-10 and TGF-β:A Potential B
The debilitating effects of lower back pain are a major health issue worldwide.A variety of factors contribute to this, ......
...
Advanced Glycation End Products promote human intervertebral disc degeneration via NLRP3inflammasome
Objective:Intervertebral disc(IVD)degeneration is widely recognized as a contributor to low back pain,neurological dysfu......
Aim:To explore the effect of inflammatory cytokines on a disintegrins and metalloproteinase with thrombospondin motifs 7......
SIRT1 expression is refractory to hypoxia and inflammatory cytokines in nucleus pulposus cells: Nove
Backgrounds:Hypoxia and a marked increase in inflammatory cytokines are common hallmarks of intervertebral disc degenera......
Impaired regulation of chondroitin sulfate biosynthesis in human intervertebral disc degeneration: r
Objective: Intervertebral disc degeneration (IDD) is characterized by loss of water content.Chondroitin sulfate (CS) is ......
[Background] Low back pain (LBP) is a common and remitting problem. One of the main cause of LBP is thought to be degene......
Development of a whole bovine long-term organ culture system that retains vertebral bone for interve
INTRODUCTION: Testing potential therapeutics in the regeneration of the disc requires the use of model systems. Although......
Dysregulated miR-127-5p contributes to extracellular matrix degradation and activation of TGF-β by t
Intervertebral disc degeneration(IDD)is associated with extracellular matrix(ECM)degradation.Dysregulated expression of ......
Effect of Survivin gene therapy via lentivirus vector on the the course of intervertebral disc degen
Gene therapy, to attenuate or reverse the degenerative process within the intervertabral disc are being developed.Here, ......
Correlation between vascular endothelial growth factors to intervertebral disc gegeneration: a Meta-
Objective: It is currently believed that cytokines and growth factors play an important role in the pathophysiology of i......
Objective:Intervertebral disc degeneration(IDD)is generally accepted as an immune-mediated inflammatory process.Thecytok......
Aggrecan gene variable number of tandem repeats and disc degeneration diseases: a case-control study
objective:Several studies have examined the association between aggrecan gene variable number of tandem repeats (VNTR) p......
Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells,a
Bcakground: Proteoglycan degradation contributing to the pathogenesis of intervertebral disc(IVD)degeneration is induced......
Pathophysiological Role of ADAM8 (A Disintegrin And Metalloproteinase 8) in intervertebral disc dege
INTRODUCTION: Chronic back pain related to intervertebral disc (IVD) degeneration is a significant problem,costing billi......
IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposu
Objective IL-1β has been reported highly expressed in degenerative intervertebral disc, and our previous study indicate......
Intervertebral disc regeneration using platelet-rich plasma containing bone marrow-derived mesenchym
Study Design.An in vivo animal study.Objective.To histologically and radiographically assess the reparative effect of a ......
Purpose This study aimed to reveal the possible genes associated with the pathogenesis of intervertebral disc degenerati......
Differentiation of adipose-derived stem cells toward nucleus pulposuslike cells induced by hypoxia a
...
椎间盘退变(IDD)是骨科脊柱疾病最常见的疾病之一，其主要包括髓核、纤维环以及软骨板的退变。椎间盘退变的病因复杂多样，发病机制尚......
Spontaneous spinal canal pneumatosis correlation with Vacuum phenomenon causing neurologic symptomsa
Background Vacuum phenomenon(VP)is a relatively common condition characterized by the accumulation of gas in the deg......
目的探讨腰椎侧前方椎体间融合术（lumbar lateral anterior interbody fusion，LLIF）治疗退行性腰椎侧凸的可行性及其早期临床疗效。方......
目的评估Dynesys混搭手术（部分节段采用Dynesys非融合固定，另部分节段采用Dynesys联合椎间融合器融合固定）治疗腰椎退行性疾病（lumbar ......
目的探讨Waveflex半刚性内固定系统联合后路腰椎椎间融合术（posterior lumbar interbody fusion，PLIF）治疗双节段腰椎退变性疾病的中......
目的探讨Dynesys动态固定与融合固定对2~4节段腰椎退行性疾病矢状面序列参数的影响。方法回顾性分析2014年3月至2019年7月接受减压......
Karacoline, identified by network pharmacology, reduces degradation of the extracellular matrix in i
Karacoline is a compound found in the plant Aconitum kusnezoffii Reichb. Although Aconitum kusnezoffii Reichb is widely ......
A porous poly(lactic-co-glycolic acid) scaffold induces innervation in a rabbit model of disc degene
into the degenerated intervertebral disc....
营养供应障碍是椎间盘退变的原因之一。椎体终板是椎间盘营养通路中的重要组成部分，其结构的变化对椎间盘营养通路有重要影响，因此研......
腰椎间盘退变是一系列腰椎退行性疾病(腰椎间盘突出症、退变性腰椎滑脱及腰椎失稳等)的前提和病理基础,主要病理表现主要为髓核细......
椎间盘退变的主要特征是蛋白多糖的丢失、水含量的下降以及细胞衰老、凋亡的增加.目前的临床治疗方案注重的是症状的缓解,无法在真......
Degenerative disc disease ( DDD ) is one of the leading causes of low back pain in the adult population, and the surgica......
目的探讨单节段、双节段和三节段后路椎间融合器置入椎弓根内固定术( posterior lumbar interbody fusion，PLIF )对融合节段邻近节......
目的：探讨Wallis系统治疗腰椎退行性疾病的中期临床疗效及适应证。方法回顾性分析2007年5月至2012年3月，应用Wallis棘突间动态稳定系......
